The future of museum is on the immateriality, affordances, interactions, processes, artificial organisms, cyber-spaces. After an era of museography, of inorganic taxonomic museums, the short life of virtual museums, the future will be on cyber-museums: borderless, distributed, embodied and able to reproduce new knowledge in different forms, layout and rhizomes. The Internet of Things, augmented reality technologies, new data analyses of artifacts, virtual reality systems, body sensors and simulations associated to new forms of engagement are going to transform missions, roles, goals and communication of museums and collections. The transformation of museums in more dynamic, flexible and open institutions is a challenge of this century and, more importantly, this trend generates new job positions and different professional profiles at the level of cultural resource management, museum communication and technological research. The core of the course will be in digital lab sessions which will be focused on the virtual reconstruction on lost heritage and, more specifically, on museums and sites destroyed and damaged by ISIS and other conflicts in Iraq and in the Middle East such as Hatra, Nineveh, Nimrud, Baghdad.